Hydrochloric Acid → 1-Ethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

HRID 1967870노트

반응식

HRID 1967870 반응식
[CH2:1]([N:3]1[CH:8]=[C:7]([C:9]([O:11]C)=[O:10])[CH:6]=[CH:5][C:4]1=[O:13])[CH3:2].O.[OH-].[Li+].Cl>O.CO>[CH2:1]([N:3]1[CH:8]=[C:7]([C:9]([OH:11])=[O:10])[CH:6]=[CH:5][C:4]1=[O:13])[CH3:2]

참가 물질

6

반응물 3

HCID 313Hydrochloric AcidHCID 168937Lithium hydroxide, monohydrateHCID 12633571Methyl 1-ethyl-6-oxo-1,6-dihydropyridine-3-carboxylate

생성물 1

HCID 99896011-Ethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid수율 65%

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

실험 절차

Methyl 1-ethyl-2-oxo-1,2-dihydropyridine-5-carboxylate (375 mg, 2.07 mmol) obtained in Step 4 was dissolved in a mixed solvent (1:1) (20 mL) of water and methanol, and lithium hydroxide monohydrate (191 mg, 4.55 mmol) was added thereto, followed by stirring at room temperature for 1 hour. The reaction mixture was neutralized with 3 mol/L hydrochloric acid added thereto, and the precipitated solid was collected by filtration to afford the entitled Compound u (224 mg, 65%).

후처리

  1. additionwas added
  2. additionadded
  3. filtrationthe precipitated solid was collected by filtration

출처 및 근거

ORD 기록
ord-ff934ea9a7e84261ae0412972e429f6c
출처 데이터셋
uspto-grants-2013_04
특허 번호
US08420827B2

반응 노트

불러오는 중…