Potassium Carbonate → HCID 136374662, compound

HRID 1967908Notes

Reaction equation

HRID 1967908 reaction equation
C([O:3][CH:4](OCC)[C:5]1[CH:10]=[CH:9][C:8]([CH:11]2[C:16]3=[N:17][NH:18][C:19](=[O:24])[C:20]4[CH:21]=[CH:22][CH:23]=[C:14]([C:15]=43)[NH:13][CH:12]2[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[CH:7][CH:6]=1)C.C(=O)([O-])[O-].[K+].[K+]>Cl>[O:24]=[C:19]1[C:20]2[CH:21]=[CH:22][CH:23]=[C:14]3[NH:13][CH:12]([C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=4)[CH:11]([C:8]4[CH:9]=[CH:10][C:5]([CH:4]=[O:3])=[CH:6][CH:7]=4)[C:16]([C:15]=23)=[N:17][NH:18]1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 136374696HCID 136374696, compound

Product 1

HCID 136374662HCID 136374662, compoundYield 69%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A mixture of 9-(4-(diethoxymethyl)phenyl)-8-phenyl-8,9-dihydro-2H-pyrido[4,3,2-de]phthalazin-3(7H)-one (270 mg, 0.61 mmol) in 3N hydrochloric acid (10 mL) was stirred at room temperature for 3 hr. The mixture was then adjusted to pH=8 with potassium carbonate. The resulting suspension was filtered to give 4-(3-oxo-8-phenyl-3,7,8,9-tetrahydro-2H-pyrido[4,3,2-de]phthalazin-9-yl)benzaldehyde (140 mg, yield: 69%) as a light yellow solid.

Workup

  1. filtrationThe resulting suspension was filtered

Sources & evidence

ORD record
ord-44677d85353d42f28d9c1db7c21f971b
Source dataset
uspto-grants-2013_04
Patent number
US08420650B2

Reaction notes

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