反应详情

A thoroughly dried three-necked round-bottom flask was equipped with reflux condenser, addition funnel and argon inlet. Then magnesium powder (7.5 g, 311 mmol, activated by iodine) and dry THF (300 mL) were placed into this apparatus. A solution of 1,4-dibromobenzene (73.5 g, 311 mmol) in dry THF (200 mL) was slowly added at such a rate that the mixture maintained at reflux. When the addition was completed the mixture was refluxed for additional 2 hrs. After cooling to room temperature, the solution was added into a solution of tert-butyl 2-oxopyrrolidine-1-carboxylate (48 g, 260 mmol) in THF (320 mL) at −78° C. and the mixture was stirred at −78° C. for 2 hrs. The solution was warmed to ambient temperature and stirred for another 10 hrs before quenching with water. Hydrochloric acid (1 N, 100 mL) was added and the mixture was stirred at ambient temperature for 10 minutes. The mixture was concentrated and the residue was partitioned between ethyl acetate and brine. The organic phase was dried over magnesium sulfate and concentrated in vacuo to afforded the crude product, which was purified by column chromatography (EtOAc:DCM:hexane=1:1:15) to give the title compound as a white solid (53 g, yield 60%). LC-MS (ESI) m/z: 342 (M+1)+.

1. customA thoroughly dried three-necked round-bottom flask was equipped
2. temperaturewith reflux
3. additioncondenser, addition funnel and argon inlet
4. temperaturemaintained
5. temperatureat reflux
6. additionWhen the addition
7. temperaturewas refluxed for additional 2 hrs
8. temperatureThe solution was warmed to ambient temperature
9. stirringstirred for another 10 hrs
10. custombefore quenching with water
11. additionHydrochloric acid (1 N, 100 mL) was added
12. stirringthe mixture was stirred at ambient temperature for 10 minutes
13. concentrationThe mixture was concentrated
14. customthe residue was partitioned between ethyl acetate and brine
15. dry with materialThe organic phase was dried over magnesium sulfate
16. concentrationconcentrated in vacuo
17. customto afforded the crude product, which
18. customwas purified by column chromatography (EtOAc:DCM:hexane=1:1:15)