反应详情

A mixture of (R)-5-chloro-4-((3-cyano-1-(cyclopentylamino)-1-oxopropan-2-ylamino)methyl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid, THF (5 mL), HATU (28.6 mg, 0.075 mmol) and 4-methylmorpholine (19.01 mg, 0.188 mmol) was stirred at room temperature for 2 h. The product was purified via preparative mass trigger LC-MS (AcCN/H2O, 5-90%). The fractions were collected, concentrated, and dried in vacuo to afford the title compound. [M+H] calc'd for C25H24ClN5O4S, 526; found, 526.2.

1. customThe product was purified via preparative mass trigger LC-MS (AcCN/H2O, 5-90%)
2. customThe fractions were collected
3. concentrationconcentrated
4. customdried in vacuo