Sodium hydride → HCID 23659147, compound

HRID 1968391Notes

Reaction equation

HRID 1968391 reaction equation
[CH2:1]([S:4][C:5]1[S:9][C:8]([SH:10])=[N:7][N:6]=1)[CH:2]=[CH2:3].[H-].[Na+].Cl[C:14]1[C:15]([C:20]#[N:21])=[N:16][CH:17]=[CH:18][N:19]=1>CN(C=O)C.C1C=CC=CC=1>[CH2:1]([S:4][C:5]1[S:9][C:8]([S:10][C:14]2[C:15]([C:20]#[N:21])=[N:16][CH:17]=[CH:18][N:19]=2)=[N:7][N:6]=1)[CH:2]=[CH2:3]

Participants

6

Reactant 3

HCID 24758Sodium hydrideHCID 2924653-Chloropyrazine-2-carbonitrileHCID 178460820HCID 178460820, compound

Product 1

HCID 23659147HCID 23659147, compound

Reagents, catalysts & solvents 2

HCID 241BenzeneSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
85 °C

Procedure

The title compound was prepared according to the procedure described in Example 1 by using 5-(allylthio)-1,3,4-thiadiazole-2-thiol (460 mg, 2.42 mmol), NaH (60% dispersion in mineral oil, 107 mg, 2.66 mmol), and 3-chloropyrazine-2-carbonitrile (338 mg, 2.42 mmol) in DMF and benzene (8 ml, 1/1) by stirring at 85° C. under nitrogen atmosphere overnight.

Sources & evidence

ORD record
ord-02064d56c4eb426e956055949d269025
Source dataset
uspto-grants-2013_04
Patent number
US08426358B2

Reaction notes

Loading…