Sodium hydride → 3-(5-(isopropylthio)-4-methyl-4H-1,2,4-triazol-3-ylthio)pyrazine-2-carbonitrile

HRID 1968399Notes

Reaction equation

HRID 1968399 reaction equation
[CH:1]([S:4][C:5]1[N:6]([CH3:11])[C:7]([SH:10])=[N:8][N:9]=1)([CH3:3])[CH3:2].[H-].[Na+].Cl[C:15]1[C:16]([C:21]#[N:22])=[N:17][CH:18]=[CH:19][N:20]=1>CN(C=O)C.C1C=CC=CC=1>[CH:1]([S:4][C:5]1[N:6]([CH3:11])[C:7]([S:10][C:15]2[C:16]([C:21]#[N:22])=[N:17][CH:18]=[CH:19][N:20]=2)=[N:8][N:9]=1)([CH3:3])[CH3:2]

Participants

6

Reactant 3

HCID 24758Sodium hydrideHCID 2924653-Chloropyrazine-2-carbonitrileHCID 178460819HCID 178460819, compound

Product 1

HCID 584027903-(5-(isopropylthio)-4-methyl-4H-1,2,4-triazol-3-ylthio)pyrazine-2-carbonitrile

Reagents, catalysts & solvents 2

HCID 241BenzeneSolventHCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared according to Example 1 by using 5-(isopropylthio)-4-methyl-4H-1,2,4-triazole-3-thiol (379 mg, 2.00 mmol), NaH (60% dispersion in mineral oil, 88 mg, 2.20 mmol), and 3-chloropyrazine-2-carbonitrile (280 mg, 2.00 mmol) in DMF and benzene (6 ml, 1/1) by stirring at room temperature under nitrogen atmosphere for 2 hr.

Sources & evidence

ORD record
ord-f99e275b8cb7460295deb33364550838
Source dataset
uspto-grants-2013_04
Patent number
US08426358B2

Reaction notes

Loading…