Sodium hydride → HCID 23659733, compound

HRID 1968402Notes

Reaction equation

HRID 1968402 reaction equation
[CH2:1]([C:5]1[S:9][C:8]([SH:10])=[N:7][N:6]=1)[CH2:2][CH2:3][CH3:4].[H-].[Na+].Cl[C:14]1[C:15]([C:20]#[N:21])=[N:16][CH:17]=[CH:18][N:19]=1>CN(C=O)C.C1C=CC=CC=1>[CH2:1]([C:5]1[S:9][C:8]([S:10][C:14]2[C:15]([C:20]#[N:21])=[N:16][CH:17]=[CH:18][N:19]=2)=[N:7][N:6]=1)[CH2:2][CH2:3][CH3:4]

Participants

6

Reactant 3

HCID 24758Sodium hydrideHCID 2924653-Chloropyrazine-2-carbonitrileHCID 178441964HCID 178441964, compound

Product 1

HCID 23659733HCID 23659733, compound

Reagents, catalysts & solvents 2

HCID 241BenzeneSolventHCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared according to Example 1 by using 5-butyl-1,3,4-thiadiazole-2-thiol (260 mg, 1.49 mmol), NaH (60% dispersion in mineral oil, 66 mg, 1.65 mmol), and 3-chloropyrazine-2-carbonitrile (210 mg, 1.50 mmol) in DMF and benzene (4 ml, 1/1) by stirring at room temperature under nitrogen atmosphere for 3 hr.

Sources & evidence

ORD record
ord-26be253ec505466db7d242eca878f810
Source dataset
uspto-grants-2013_04
Patent number
US08426358B2

Reaction notes

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