Sodium hydride → HCID 23659515, compound

HRID 1968403Notes

Reaction equation

HRID 1968403 reaction equation
[CH3:1][N:2]1[CH:6]=[N:5][N:4]=[C:3]1[SH:7].[H-].[Na+].Cl[C:11]1[C:12]([C:17]#[N:18])=[N:13][CH:14]=[CH:15][N:16]=1>CN(C=O)C.C1C=CC=CC=1>[CH3:1][N:2]1[CH:6]=[N:5][N:4]=[C:3]1[S:7][C:11]1[C:12]([C:17]#[N:18])=[N:13][CH:14]=[CH:15][N:16]=1

Participants

6

Reactant 3

HCID 24758Sodium hydrideHCID 2924653-Chloropyrazine-2-carbonitrileHCID 178481306HCID 178481306, compound

Product 1

HCID 23659515HCID 23659515, compound

Reagents, catalysts & solvents 2

HCID 241BenzeneSolventHCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared according to Example 1 by using 4-methyl-4H-1,2,4-triazole-3-thiol (230.5 mg, 2.00 mmol), NaH (60% dispersion in mineral oil, 88 mg, 2.20 mmol), and 3-chloropyrazine-2-carbonitrile (280 mg, 2.00 mmol) in DMF and benzene (6 ml, 1/1) by stirring at room temperature under nitrogen atmosphere for 4 hr.

Sources & evidence

ORD record
ord-3815f743b9d64410807d8d7babaada68
Source dataset
uspto-grants-2013_04
Patent number
US08426358B2

Reaction notes

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