Sodium hydride → HCID 23659516, compound

HRID 1968404Notes

Reaction equation

HRID 1968404 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[SH:7].[H-].[Na+].Cl[C:11]1[C:12]([C:17]#[N:18])=[N:13][CH:14]=[CH:15][N:16]=1>CN(C=O)C.C1C=CC=CC=1>[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[S:7][C:11]1[C:12]([C:17]#[N:18])=[N:13][CH:14]=[CH:15][N:16]=1

Participants

6

Reactant 3

HCID 24758Sodium hydrideHCID 2924653-Chloropyrazine-2-carbonitrileHCID 178480602HCID 178480602, compound

Product 1

HCID 23659516HCID 23659516, compound

Reagents, catalysts & solvents 2

HCID 241BenzeneSolventHCID 6228DimethylformamideSolvent

Procedure

The title compound was prepared according to Example 1 by using 1-methyl-1H-imidazole-2-thiol (228 mg, 2.00 mmol), NaH (60% dispersion in mineral oil, 88 mg, 2.20 mmol), and 3-chloropyrazine-2-carbonitrile (280 mg, 2.00 mmol) in DMF and benzene (6 ml, 1/1) by stirring at room temperature under nitrogen atmosphere for 4 hr.

Sources & evidence

ORD record
ord-8db6aaa6582c46dda43c44a8981b8c57
Source dataset
uspto-grants-2013_04
Patent number
US08426358B2

Reaction notes

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