HCID 178476501, compound → [3-(4-{1,2-Dimethyl-1-[5-(pyridin-2-ylmethoxy)pyridin-2-yl]propyl}phenyl)-1,2,4-oxadiazol-5-yl]methyl acetate

HRID 1968666Notes

Reaction equation

HRID 1968666 reaction equation
[C:1]([O:4][CH2:5][C:6](/[N:8]=[C:9](/[NH2:35])\[C:10]1[CH:15]=[CH:14][C:13]([C:16]([CH3:34])([C:20]2[CH:25]=[CH:24][C:23]([O:26][CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=3)=[CH:22][N:21]=2)[CH:17]([CH3:19])[CH3:18])=[CH:12][CH:11]=1)=[O:7])(=[O:3])[CH3:2]>C1(C)C(C)=CC=CC=1>[C:1]([O:4][CH2:5][C:6]1[O:7][N:35]=[C:9]([C:10]2[CH:11]=[CH:12][C:13]([C:16]([CH3:34])([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH2:27][C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][N:29]=4)=[CH:22][N:21]=3)[CH:17]([CH3:19])[CH3:18])=[CH:14][CH:15]=2)[N:8]=1)(=[O:3])[CH3:2]

Participants

3

Reactant 1

HCID 178476501HCID 178476501, compound

Product 1

HCID 57910807[3-(4-{1,2-Dimethyl-1-[5-(pyridin-2-ylmethoxy)pyridin-2-yl]propyl}phenyl)-1,2,4-oxadiazol-5-yl]methyl acetate

Reagents, catalysts & solvents 1

HCID 7237O-XyleneSolvent

Procedure

A stirred solution of 3b (0.896 mmol) in xylene (6.00 mL) was heated to 110° C. for approximately 1 h. After cooling to rt, the reaction mixture was concentrated in vacuo to afford the title compound 3c, which was used without further purification in the subsequent reaction. m/z (ES) 473 (MH)+.

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-1dc3a3bbb5fd4217b5febcd6a44f47e9
Source dataset
uspto-grants-2013_04
Patent number
US08426413B2

Reaction notes

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