反应详情

NaH (0.975 mol) was washed with hexane. After the hexane was decanted off, the NaH was stirred in DMF (1950 mL) at room temperature. Morpholin-4-yl-phenyl-acetonitrile (0.70 mol) in DMF (300 mL) was added dropwise under N2 gas. The reaction mixture was stirred at room temperature for 2 hours. The reaction mixture was cooled in an ice bath and 4-chloro-2-dimethoxymethyl-1-nitrobenzene (0.86 mol) in DMF (150 mL) was added dropwise. The reaction mixture was stirred at 0° C. for 2 hours and at room temperature overnight. The reaction mixture was poured on ice/water and extracted with diisopropyl ether. The organic layer washed with water, dried (MgSO4) and evaporated to yield the title compound as a solid.

1. customAfter the hexane was decanted off
2. stirringThe reaction mixture was stirred at room temperature for 2 hours
3. temperatureThe reaction mixture was cooled in an ice bath
4. stirringThe reaction mixture was stirred at 0° C. for 2 hours and at room temperature overnight
5. additionThe reaction mixture was poured on ice/water
6. extractionextracted with diisopropyl ether
7. washThe organic layer washed with water
8. dry with materialdried (MgSO4)
9. customevaporated