反应详情

To a solution of 4-methyl-3-nitrobenzoyl chloride (2.0 g) in dichloromethane (20 ml), a solution of triethylamine (0.7 ml) and 3-chloro-4-fluoroaniline (0.7 g) in dichloromethane (15 ml) was added dropwise in an ice-bath with the temperature no more than 5° C. After addition, the reaction was carried out for 30 min in an ice-bath, and then at room temperature overnight. The completion of reaction was indicated by TLC. Then potassium carbonate solution (10%) was added to precipitate a solid. The mixture was left to stand, and filtered. The filter cake was washed with water, and dried to give a pale yellow powdered solid.

1. additionAfter addition
2. customat room temperature
3. customovernight
4. customThe completion of reaction
5. customto precipitate a solid
6. waitThe mixture was left
7. filtrationfiltered
8. washThe filter cake was washed with water
9. customdried
10. customto give a pale yellow powdered solid