Potassium Carbonate → HCID 178515017, compound

HRID 1968964Notes

Reaction equation

HRID 1968964 reaction equation
C(O[C:4]([N:6]1[C:10](=[O:11])[C:9]2=[CH:12][CH:13]=[CH:14][CH:15]=[C:8]2[C:7]1=[O:16])=O)C.Cl.[OH:18][C@H:19]1[CH2:24][CH2:23][C@H](N)[CH2:21][CH2:20]1.C(=O)([O-])[O-].[K+].[K+]>O>[OH:18][C@H:19]1[CH2:24][CH2:23][C@H:4]([N:6]2[C:7](=[O:16])[C:8]3=[CH:15][CH:14]=[CH:13][CH:12]=[C:9]3[C:10]2=[O:11])[CH2:21][CH2:20]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 31187N-CarbethoxyphthalimideHCID 178479278HCID 178479278, compound

Product 1

HCID 178515017HCID 178515017, compoundYield 84.2%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

N-Ethoxycarbonylphthalimide (100 g; 0.46 mol) was added to a mixture of trans-4-hydroxycyclohexylamine hydrochloride (69 g; 0.46 mol), potassium carbonate (158 g; 1.15 mol) and water (1 L) at room temperature. After stirring for 3 h the title compound (95 g) was isolated by filtration, washing with water then ethyl acetate.

Sources & evidence

ORD record
ord-c646410e023c4063af5f71dee5842292
Source dataset
uspto-grants-2013_04
Patent number
US08426443B2

Reaction notes

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