Potassium Carbonate → HCID 58288506, compound

HRID 1969086Notes

Reaction equation

HRID 1969086 reaction equation
F[C:2]1[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=1[CH:4]=[O:5].[CH2:13]([O:15][C:16](=[O:27])[CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([OH:26])[CH:19]=1)[CH3:14].C(=O)([O-])[O-].[K+].[K+]>O1CCOCC1>[CH2:13]([O:15][C:16](=[O:27])[CH2:17][C:18]1[CH:23]=[CH:22][C:21]([O:24][CH3:25])=[C:20]([O:26][C:2]2[CH:9]=[CH:8][C:7]([N+:10]([O-:12])=[O:11])=[CH:6][C:3]=2[CH:4]=[O:5])[CH:19]=1)[CH3:14]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 27347702-Fluoro-5-nitrobenzaldehydeHCID 5324706Ethyl 2-(3-hydroxy-4-methoxyphenyl)acetate

Product 1

HCID 58288506HCID 58288506, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

2-Fluoro-5-nitrobenzaldehyde (8.8 g, 52 mmol), (3-hydroxy-4-methoxy-phenyl)-acetic acid ethyl ester (10.0 g, 48 mmol), and potassium carbonate (10.0 g, 69 mmol) were combined in 1,4-dioxane (150 mL), and the reaction was stirred at 100° C. for 24 hours. The mixture was worked up to give the title compound.

Sources & evidence

ORD record
ord-9f8001a4f35e41d7a18c494b191ae11e
Source dataset
uspto-grants-2013_04
Patent number
US08426449B2

Reaction notes

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