Ethylamine → HCID 58288476, compound

HRID 1969087Notes

Reaction equation

HRID 1969087 reaction equation
[CH2:1]([O:3][C:4](=[O:26])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([O:14][C:15]2[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][C:16]=2[CH:24]=O)[CH:7]=1)[CH3:2].[CH2:27]([NH2:29])[CH3:28].C([BH3-])#N.[Na+]>C(Cl)Cl>[CH2:1]([O:3][C:4](=[O:26])[CH2:5][C:6]1[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[C:8]([O:14][C:15]2[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][C:16]=2[CH2:24][NH:29][CH2:27][CH3:28])[CH:7]=1)[CH3:2]

Participants

5

Reactant 3

HCID 6341EthylamineHCID 5003444Sodium cyanoborohydrideHCID 58288506HCID 58288506, compound

Product 1

HCID 58288476HCID 58288476, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

[3-(2-Formyl-4-nitro-phenoxy)-4-methoxy-phenyl]-acetic acid ethyl ester (1.0 g, 2.79 mmol), ethylamine (2M in THF; 2.8 mL, 5.6 mmol), and sodium cyanoborohydride (0.26 g, 4.2 mmol) were combined in CH2Cl2 (30 mL), and the reaction was stirred at room temperature for 3 hours. After work-up, the mixture was concentrated to give the title compound.

Workup

  1. concentrationAfter work-up, the mixture was concentrated

Sources & evidence

ORD record
ord-5fb5000e6b17484f876be21bd036822f
Source dataset
uspto-grants-2013_04
Patent number
US08426449B2

Reaction notes

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