Thioacetamide → 4-(Benzyloxy)-3-cyanobenzenecarbothioamide

HRID 1969141Notes

Reaction equation

HRID 1969141 reaction equation
Cl.O1CCOCC1.[CH2:8]([O:15][C:16]1[CH:23]=[CH:22][C:19]([C:20]#[N:21])=[CH:18][C:17]=1[C:24]#[N:25])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C(N)(=[S:28])C>CN(C=O)C>[CH2:8]([O:15][C:16]1[CH:23]=[CH:22][C:19]([C:20](=[S:28])[NH2:21])=[CH:18][C:17]=1[C:24]#[N:25])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

Participants

5

Reactant 3

HCID 2723949ThioacetamideHCID 153266114-(Benzyloxy)isophthalonitrileHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 866261374-(Benzyloxy)-3-cyanobenzenecarbothioamide

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
60 °C

Procedure

A 4M HCl/1,4-dioxane solution was added to a DMF solution of 4-(benzyloxy)isophthalonitrile and thioacetamide, followed by stirring at 60° C. to obtain 4-(benzyloxy)-3-cyanobenzenecarbothioamide. AP: 291(Na).

Sources & evidence

ORD record
ord-64262bcefce7413c8bdafadd44ce69f7
Source dataset
uspto-grants-2013_04
Patent number
US08426453B2

Reaction notes

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