Triethylamine → HCID 66995258, compound

HRID 1969148Notes

Reaction equation

HRID 1969148 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([C:11](Cl)=[N:12][OH:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10])#[N:2].[C:15]([O:19][CH2:20][CH3:21])(=[O:18])[C:16]#[CH:17].C(N(CC)CC)C>C1COCC1>[C:1]([C:3]1[CH:4]=[C:5]([C:11]2[CH:17]=[C:16]([C:15]([O:19][CH2:20][CH3:21])=[O:18])[O:13][N:12]=2)[CH:6]=[CH:7][C:8]=1[O:9][CH3:10])#[N:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 12182Ethyl propiolateHCID 130172856HCID 130172856, compound

Product 1

HCID 66995258HCID 66995258, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
40 °C

Procedure

3-Cyano-N-hydroxy-4-methoxybenzenecaboximidoyl chloride, ethyl propiolate and triethylamine were dissolved in a THF solution, followed by stirring at 40° C. to obtain ethyl 3-(3-cyano-4-methoxyphenyl)-5-isoxazolecarboxylate. AP: 295.

Sources & evidence

ORD record
ord-e9f919fdd4954b63816c6f75a1968a5a
Source dataset
uspto-grants-2013_04
Patent number
US08426453B2

Reaction notes

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