反应详情

To a solution of (4-oxaspiro[2.4]heptane-6-yl)methanesulfonate (336 mg, 1.75 mmol) in dry THF (3 mL) was added 3-aminopropan-1-ol (656.3 mg, 8.75 mmol, TCI). The reaction was refluxed overnight. The mixture was concentrated in vacuo to give a brown residue, which was chromatographed with a silica gel column (8:1 (v/v) EtOAc/MeOH) to give the title compound as pale yellow oil (280 mg, 93%).

1. temperatureThe reaction was refluxed overnight
2. concentrationThe mixture was concentrated in vacuo
3. customto give a brown residue, which
4. customwas chromatographed with a silica gel column (8:1 (v/v) EtOAc/MeOH)