反应详情

765 mg (2.950 mmol) of 2-amino-6-sulfanyl-4-(1,3-thiazol-5-yl)pyridine-3,5-dicarbonitrile, together with 792 mg (3.245 mmol) of 4-(chloromethyl)-2-(4-chlorophenyl)-1,3-thiazole and 744 mg (8.850 mmol) of sodium bicarbonate, were stirred in 15 ml DMF at room temperature for 1 h. The reaction mixture was added to 150 ml of acetonitrile, and 100 ml of water were then added. The resulting precipitate was filtered off and washed initially with a little acetonitrile and then with diethyl ether. Drying under reduced pressure gave 889 mg (53% of theory) of the target compound.

1. additionwere then added
2. filtrationThe resulting precipitate was filtered off
3. washwashed initially with a little acetonitrile
4. customDrying under reduced pressure
5. customgave 889 mg (53% of theory) of the target compound