反应详情

100 mg (0.206 mmol) of 2-chloro-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)-4-(1,3-thiazol-5-yl)pyridine-3,5-dicarbonitrile, together with 45 mg (0.411 mmol) of azetidin-3-ol hydrochloride and 53 mg (0.411 mmol) of N-ethyl-N-(1-methylethyl)propan-2-amine, were dissolved in 1.5 ml of THF. The mixture was stirred at room temperature for two hours, and the product was then purified by preparative HPLC (acetonitrile/water: 10:90→95:5, 0.1% TFA added). This gave 40 mg (37% of theory) of the target compound.

1. customthe product was then purified by preparative HPLC (acetonitrile/water: 10:90→95:5, 0.1% TFA added)