Benzyl Bromide → HCID 21139221, compound

HRID 1969963Notes

Reaction equation

HRID 1969963 reaction equation
[O:1]=[C:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([S:11](Cl)(=[O:13])=[O:12])[CH:8]=2)[NH:3]1.Br[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[C:17]1([CH2:16][S:11]([C:7]2[CH:8]=[C:9]3[C:4](=[CH:5][CH:6]=2)[NH:3][C:2](=[O:1])[CH2:10]3)(=[O:13])=[O:12])[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 2

HCID 7498Benzyl BromideHCID 49625062-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride

Product 1

HCID 21139221HCID 21139221, compoundYield 87%

Procedure

5-Phenylmethanesulfonyl-1,3-dihydro-indol-2-one was prepared according to the method described by Jiong Jack Chen et al. (Organic Process Research and Development, 2003, 7, 313-317) from 1 g (4.32 mmol) of 2-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride and 0.51 mL (4.32 mmol) of bromomethyl-benzene. After filtration and washing with acetone, 1.08 g (87%) of 5-phenylmethanesulfonyl-1,3-dihydro-indol-2-one is obtained in the form of a white solid.

Workup

  1. custom5-Phenylmethanesulfonyl-1,3-dihydro-indol-2-one was prepared
  2. filtrationAfter filtration
  3. washwashing with acetone

Sources & evidence

ORD record
ord-09150f3ce2b944879c4ca4c0b7a8995a
Source dataset
uspto-grants-2013_04
Patent number
US08426437B2

Reaction notes

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