反应详情

温度

100 °C

0.5-2 ml Microwave vial was charged with (S)-2′-bromo-7′-(pyrimidin-5-yl)-5H-spiro[oxazole-4,9′-xanthen]-2-amine (100 mg, 0.244 mmol), pyridin-3-ylboronic acid (38.7 mg, 0.315 mmol), dichlorobis(di-t-butyl-4-dimethylaminophenylphosphine)palladium (II) (7.44 mg, 10.51 μmol) and potassium carbonate (87 mg, 0.630 mmol), dioxane (1 ml) and water (0.12 ml) were added and the vial was sealed and heated at 100° C. in the microwave oven (Biotage) for 1 hr. The mixture was diluted with DCM, filtered through Celite, concentrated and purified by flash chromatography on silica gel (12 g column, 20-100% DCM/MeOH/NH4OH in DCM) to afford (R)-2′-(pyridin-3-yl)-7′-(pyrimidin-5-yl)-5H-spiro[oxazole-4,9′-xanthen]-2-amine as yellowish solid.

1. additionwere added
2. customthe vial was sealed
3. filtrationfiltered through Celite
4. concentrationconcentrated
5. custompurified by flash chromatography on silica gel (12 g column, 20-100% DCM/MeOH/NH4OH in DCM)