HRID1970530

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3939

Lithium hydroxide anhydrous

HLiO

结构：COC(=O)[C@H](CCC(=O)OC(C)(C)C)NC(=O)c1cc(OCC(=O)N2CCC[C@H]2C(=O)NCCF)n(-c2ccccc2)n1

HCID86650478

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)OC(=O)CC[C@H](NC(=O)c1cc(OCC(=O)N2CCC[C@H]2C(=O)NCCF)n(-c2ccccc2)n1)C(=O)O

HCID86650477

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

To a solution of 1.30 g (S)-2-({5-[2-((S)-2-(2-Fluoro-ethylcarbamoyl)-pyrrolidin-1-yl)-2-oxo-ethoxy]-1-phenyl-1H-pyrazole-3-carbonyl}-amino)-pentanedioic acid 5-tert-butyl ester 1-methyl ester in 9 ml THF were added 52 mg LiOH (as solution in 3 ml water). After 2 h the reaction mixture was neutralized with Amberlite IR-120, filtrated and washed with methanol.

WORKUP

后处理

filtrationfiltrated
washwashed with methanol

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-16eeb71852944bbe88a8e3faa9ed99d3
来源数据集: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08426420B2
来源说明: uspto-grants-2013_04

反应 SMILES

C[O:2][C:3](=[O:43])[C@@H:4]([NH:14][C:15]([C:17]1[CH:21]=[C:20]([O:22][CH2:23][C:24]([N:26]2[CH2:30][CH2:29][CH2:28][C@H:27]2[C:31](=[O:36])[NH:32][CH2:33][CH2:34][F:35])=[O:25])[N:19]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[N:18]=1)=[O:16])[CH2:5][CH2:6][C:7]([O:9][C:10]([CH3:13])([CH3:12])[CH3:11])=[O:8].[Li+].[OH-]>C1COCC1>[C:10]([O:9][C:7](=[O:8])[CH2:6][CH2:5][C@H:4]([NH:14][C:15]([C:17]1[CH:21]=[C:20]([O:22][CH2:23][C:24]([N:26]2[CH2:30][CH2:29][CH2:28][C@H:27]2[C:31](=[O:36])[NH:32][CH2:33][CH2:34][F:35])=[O:25])[N:19]([C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=2)[N:18]=1)=[O:16])[C:3]([OH:43])=[O:2])([CH3:13])([CH3:11])[CH3:12]