Potassium Carbonate → HCID 59543129, compound

HRID 1971003Notes

Reaction equation

HRID 1971003 reaction equation
[CH:1]1([C@@H:4]([NH:9][C:10]2[C:22]3[C:21]4[CH:20]=[CH:19][C:18]([C:23]#[C:24][Si](C)(C)C)=[CH:17][C:16]=4[NH:15][C:14]=3[C:13]([C:29]([NH2:31])=[O:30])=[CH:12][N:11]=2)[C:5]([F:8])([F:7])[F:6])[CH2:3][CH2:2]1.C(=O)([O-])[O-].[K+].[K+]>CO.CCOC(C)=O>[CH:1]1([C@@H:4]([NH:9][C:10]2[C:22]3[C:21]4[CH:20]=[CH:19][C:18]([C:23]#[CH:24])=[CH:17][C:16]=4[NH:15][C:14]=3[C:13]([C:29]([NH2:31])=[O:30])=[CH:12][N:11]=2)[C:5]([F:8])([F:6])[F:7])[CH2:3][CH2:2]1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 59543128HCID 59543128, compound

Product 1

HCID 59543129HCID 59543129, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a stirred solution of 1-{[(1R)-1-Cyclopropyl-2,2,2-trifluoroethyl]amino}-7-[(trimethylsilyl)ethynyl]-5H-pyrido[4,3-b]indole-4-carboxamide (0.15 g, 0.33 mmol) in MeOH (3.3 mL) was added potassium carbonate (0.055 g, 0.40 mmol). The reaction mixture was left to stir at room temperature for 16 h, diluted with EtOAc, washed with water and brine, dried (sodium sulfate), and concentrated to give the title compound. LRMS (APCI) calc'd for (C19H15F3N4O) [M+H]+, 373.1. found 373.1.

Workup

  1. waitThe reaction mixture was left
  2. washwashed with water and brine
  3. dry with materialdried (sodium sulfate)
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-8d65e8417a8f4230b0ff95a0b0a1a8ec
Source dataset
uspto-grants-2013_04
Patent number
US08431569B2

Reaction notes

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