反应详情

Sodium (0.75 g, 32.94 mmol) and ethanol (20 mL) were introduced in a flask. Once all the sodium had dissolved, 3-methylbutanimidamide hydrochloride (1.5 g, 10.98 mmol) and diethyl malonate (1.67 mL, 10.98 mmol) were added. It was stirred for 1 hour at room temperature and for 5 hours under reflux. The reaction crude was cooled at room temperature and concentrated to dryness. The solid obtained was dissolved in water and the pH was adjusted to 5 with acetic acid. The precipitate formed was filtered providing 1.5 g of the title compound (yield: 81%).

1. temperatureunder reflux
2. customThe reaction crude
3. temperaturewas cooled at room temperature
4. concentrationconcentrated to dryness
5. customThe solid obtained
6. customThe precipitate formed
7. filtrationwas filtered