2-Aminothiazole → N-(thiazol-2-yl)-1H-imidazole-1-carbothioamide

HRID 1971440Notes

Reaction equation

HRID 1971440 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.[C:7](N1C=CN=C1)([N:9]1[CH:13]=[CH:12][N:11]=[CH:10]1)=[S:8]>C(#N)C>[S:3]1[CH:4]=[CH:5][N:6]=[C:2]1[NH:1][C:7]([N:9]1[CH:13]=[CH:12][N:11]=[CH:10]1)=[S:8]

Participants

4

Reactant 2

HCID 21552-AminothiazoleHCID 802641,1'-Thiocarbonyldiimidazole

Product 1

HCID 10750950N-(thiazol-2-yl)-1H-imidazole-1-carbothioamideYield 89.1%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

35 g (349.5 mmol) of 2-aminothiazole and 62.3 g (349.5 mmol) thiocarbonyldiimidazole were stirred in 1300 ml acetonitrile for a total of four days at room temperature. Filtration of the precipitate formed and drying yielded 65.5 g of light yellow solid.

Workup

  1. filtrationFiltration of the precipitate
  2. customformed
  3. customdrying

Sources & evidence

ORD record
ord-448018d97d204e7988ec440906e6f1ab
Source dataset
uspto-grants-2013_04
Patent number
US08431604B2

Reaction notes

Loading…