反应详情

To a solution of 750 mg of 1a and 1 ml of triethyl amine in 15 ml of diethyl ether, was added dropwise at 0° C. 400 μl of methanesulfonyl chloride in 5 ml of diethyl ether. The reaction mixture was stirred for ½ hr and then diluted with 30 ml of water and 5 ml of 1M K2CO3. The product was extracted with diethyl ether and the combined extracts were once washed with water, dried and concentrated, to provide 1.2 g of mesylate 1b; Rf 0.50 (heptane/ethyl acetate 1/1), MS-ESI: [M+1] 231.07.

1. extractionThe product was extracted with diethyl ether
2. washthe combined extracts were once washed with water
3. customdried
4. concentrationconcentrated