Tert-Butylamine → HCID 58124811, compound

HRID 1971646Notes

Reaction equation

HRID 1971646 reaction equation
CS(O[CH2:6][CH2:7][CH2:8][C:9]#[C:10][C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)(=O)=O.[C:16]([NH2:20])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([NH:20][CH2:6][CH2:7][CH2:8][C:9]#[C:10][C:11]1[S:12][CH:13]=[CH:14][CH:15]=1)([CH3:19])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 6385Tert-ButylamineHCID 581248695-(Thiophen-2-yl)pent-4-ynyl methanesulfonate

Product 1

HCID 58124811HCID 58124811, compound

Procedure

A mixture of 210 mg of 2b and 5 ml of tert-butyl amine was stirred for 4 days. The reaction mixture was concentrated and the residue was treated with 20 ml of 1M K2CO3 and the product was extracted into ethyl acetate. The organic layer was washed once with water, dried and concentrated, to provide 250 mg of 2c as a colorless oil.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. additionthe residue was treated with 20 ml of 1M K2CO3
  3. extractionthe product was extracted into ethyl acetate
  4. washThe organic layer was washed once with water
  5. customdried
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-8e0de67fab5d417e84bc9474c78ac7a0
Source dataset
uspto-grants-2013_04
Patent number
US08431564B2

Reaction notes

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