Acetic Anhydride → HCID 58124814, compound

HRID 1971710Notes

Reaction equation

HRID 1971710 reaction equation
[CH:1]([N:4]1[C:28](=[O:29])[C:27]2[N:12]3[CH2:13][CH2:14][C:15]4[CH:16]=[C:17]([O:25][CH3:26])[C:18]([O:21][CH:22]([CH3:24])[CH3:23])=[CH:19][C:20]=4[C:11]3=[C:10]([C:30]3[S:31][CH:32]=[CH:33][CH:34]=3)[C:9]=2[CH2:8][NH:7][CH2:6][CH2:5]1)([CH3:3])[CH3:2].[C:35](OC(=O)C)(=[O:37])[CH3:36]>N1C=CC=CC=1.CN(C1C=CN=CC=1)C.O>[C:35]([N:7]1[CH2:8][C:9]2[C:10]([C:30]3[S:31][CH:32]=[CH:33][CH:34]=3)=[C:11]3[C:20]4[CH:19]=[C:18]([O:21][CH:22]([CH3:23])[CH3:24])[C:17]([O:25][CH3:26])=[CH:16][C:15]=4[CH2:14][CH2:13][N:12]3[C:27]=2[C:28](=[O:29])[N:4]([CH:1]([CH3:2])[CH3:3])[CH2:5][CH2:6]1)(=[O:37])[CH3:36]

Participants

6

Reactant 2

HCID 7918Acetic AnhydrideHCID 58124947HCID 58124947, compound

Product 1

HCID 58124814HCID 58124814, compound

Reagents, catalysts & solvents 3

HCID 142844-(Dimethylamino)pyridineCatalystHCID 962WaterSolventHCID 1049PyridineSolvent

Procedure

A solution of 35 mg of 14e in 250 μl of pyridine was treated with 30 μl of acetic anhydride and a catalytic amount of DMAP. After stirring ½ hr the reaction mixture was diluted with 400 μl of water and stirred for an additional 1 h. The precipitate was filtered, washed with water and dried to give 31 mg of crystalline white 14f;

Workup

  1. stirringstirred for an additional 1 h
  2. filtrationThe precipitate was filtered
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-3ce42331d4454d23a5a925b57b5620a3
Source dataset
uspto-grants-2013_04
Patent number
US08431564B2

Reaction notes

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