Acetone → HCID 68984339, compound

HRID 1971794Notes

Reaction equation

HRID 1971794 reaction equation
[CH2:1]([N:5]([CH:30]1[CH2:35][CH2:34][O:33][CH2:32][CH2:31]1)[C:6]1[C:7]([O:28][CH3:29])=[N:8][N:9]2[C:13]([C:14]3[C:19]([O:20][CH3:21])=[CH:18][C:17]([CH2:22][O:23][CH2:24][CH3:25])=[CH:16][C:15]=3[O:26][CH3:27])=[CH:12][S:11][C:10]=12)[CH2:2][CH2:3][CH3:4].CC(C)=O.[BrH:40]>O>[BrH:40].[CH2:1]([N:5]([CH:30]1[CH2:31][CH2:32][O:33][CH2:34][CH2:35]1)[C:6]1[C:7]([O:28][CH3:29])=[N:8][N:9]2[C:13]([C:14]3[C:15]([O:26][CH3:27])=[CH:16][C:17]([CH2:22][O:23][CH2:24][CH3:25])=[CH:18][C:19]=3[O:20][CH3:21])=[CH:12][S:11][C:10]=12)[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 180AcetoneHCID 260Hydrogen BromideHCID 57912459HCID 57912459, compound

Product 1

HCID 68984339HCID 68984339, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To N-butyl-3-[4-(ethoxymethyl)-2,6-dimethoxyphenyl]-6-methoxy-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine (1.02 g) was added acetone (2 mL) warmed by hot water, then hydrobromic acid (8.84M, 240 μL) was added, and the mixture was stirred. The solvent in the mixture was partially removed by blowing nitrogen stream, and the mixture was further stirred.

Workup

  1. customThe solvent in the mixture was partially removed

Sources & evidence

ORD record
ord-4e48fd961bcc471880c0ab8bbf5ae968
Source dataset
uspto-grants-2013_04
Patent number
US08431603B2

Reaction notes

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