Ethanol → HCID 68514591, compound

HRID 1971796Notes

Reaction equation

HRID 1971796 reaction equation
[CH:1]1([CH2:4][CH2:5][N:6]([CH:31]2[CH2:36][CH2:35][O:34][CH2:33][CH2:32]2)[C:7]2[C:8]([O:29][CH3:30])=[N:9][N:10]3[C:14]([C:15]4[C:20]([O:21][CH3:22])=[CH:19][C:18]([CH2:23][O:24][CH2:25][CH3:26])=[CH:17][C:16]=4[O:27][CH3:28])=[CH:13][S:12][C:11]=23)[CH2:3][CH2:2]1.C(O)C.[P:40](=[O:44])([OH:43])([OH:42])[OH:41]>C(OCC)(=O)C>[P:40]([OH:44])([OH:43])([OH:42])=[O:41].[CH:1]1([CH2:4][CH2:5][N:6]([CH:31]2[CH2:32][CH2:33][O:34][CH2:35][CH2:36]2)[C:7]2[C:8]([O:29][CH3:30])=[N:9][N:10]3[C:14]([C:15]4[C:20]([O:21][CH3:22])=[CH:19][C:18]([CH2:23][O:24][CH2:25][CH3:26])=[CH:17][C:16]=4[O:27][CH3:28])=[CH:13][S:12][C:11]=23)[CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 702EthanolHCID 1004Phosphoric AcidHCID 57912452HCID 57912452, compound

Product 1

HCID 68514591HCID 68514591, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a mixture of N-(2-cyclopropylethyl)-3-[4-(ethoxymethyl)-2,6-dimethoxyphenyl]-6-methoxy-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine (757.0 mg), ethanol (10 mL) and ethyl acetate (5 mL) was added phosphoric acid (14.6M, 101 μL). The mixture was stirred at room temperature for 5 minutes and the solvent was removed by blowing nitrogen stream and dried to obtain the title compound (856.0 mg).

Workup

  1. customthe solvent was removed
  2. customdried

Sources & evidence

ORD record
ord-e20c176b86514ee69707702f0dbfd627
Source dataset
uspto-grants-2013_04
Patent number
US08431603B2

Reaction notes

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