Methanesulfonic Acid → HCID 86635064, compound

HRID 1971797Notes

Reaction equation

HRID 1971797 reaction equation
[CH:1]1([CH2:4][CH2:5][N:6]([CH:31]2[CH2:36][CH2:35][O:34][CH2:33][CH2:32]2)[C:7]2[C:8]([O:29][CH3:30])=[N:9][N:10]3[C:14]([C:15]4[C:20]([O:21][CH3:22])=[CH:19][C:18]([CH2:23][O:24][CH2:25][CH3:26])=[CH:17][C:16]=4[O:27][CH3:28])=[CH:13][S:12][C:11]=23)[CH2:3][CH2:2]1.[CH3:37][S:38]([OH:41])(=[O:40])=[O:39]>C(OCC)(=O)C>[CH3:37][S:38]([OH:41])(=[O:40])=[O:39].[CH:1]1([CH2:4][CH2:5][N:6]([CH:31]2[CH2:32][CH2:33][O:34][CH2:35][CH2:36]2)[C:7]2[C:8]([O:29][CH3:30])=[N:9][N:10]3[C:14]([C:15]4[C:20]([O:21][CH3:22])=[CH:19][C:18]([CH2:23][O:24][CH2:25][CH3:26])=[CH:17][C:16]=4[O:27][CH3:28])=[CH:13][S:12][C:11]=23)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 57912452HCID 57912452, compound

Product 1

HCID 86635064HCID 86635064, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a mixture of N-(2-cyclopropylethyl)-3-[4-(ethoxymethyl)-2,6-dimethoxyphenyl]-6-methoxy-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine (16.2 mg) and ethyl acetate (0.5 mL) was added methanesulfonic acid (2.05 μL). The mixture was stirred at room temperature for 1 hour and the solvent was removed by blowing nitrogen stream and dried to obtain the title compound (19.2 mg).

Workup

  1. customthe solvent was removed
  2. customdried

Sources & evidence

ORD record
ord-60ef7a9c314749d59ef89a6b50b4a142
Source dataset
uspto-grants-2013_04
Patent number
US08431603B2

Reaction notes

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