Methanesulfonic Acid → HCID 86635067, compound

HRID 1971804Notes

Reaction equation

HRID 1971804 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH2:9][O:10][CH3:11])[CH:6]=[C:5]([O:12][CH3:13])[C:4]=1[C:14]1[N:15]2[N:21]=[C:20]([O:22][CH3:23])[C:19]([N:24]([CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])[CH:25]3[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)=[C:16]2[S:17][CH:18]=1.[CH3:36][S:37]([OH:40])(=[O:39])=[O:38]>C(OCC)(=O)C>[CH3:36][S:37]([OH:40])(=[O:39])=[O:38].[CH3:13][O:12][C:5]1[CH:6]=[C:7]([CH2:9][O:10][CH3:11])[CH:8]=[C:3]([O:2][CH3:1])[C:4]=1[C:14]1[N:15]2[N:21]=[C:20]([O:22][CH3:23])[C:19]([N:24]([CH2:31][CH2:32][CH2:33][CH2:34][CH3:35])[CH:25]3[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)=[C:16]2[S:17][CH:18]=1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 57912439HCID 57912439, compound

Product 1

HCID 86635067HCID 86635067, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a mixture of 3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methoxy-N-pentyl-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine (12.2 mg) and ethyl acetate (0.5 mL) was added methanesulfonic acid (1.58 μL). The mixture was stirred at room temperature for 1 hour and the solvent was removed by blowing nitrogen stream and dried to obtain the title compound (14.5 mg).

Workup

  1. customthe solvent was removed
  2. customdried

Sources & evidence

ORD record
ord-2bbbec62341e4ea19df5cfa89073291b
Source dataset
uspto-grants-2013_04
Patent number
US08431603B2

Reaction notes

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