Phosphoric Acid → HCID 68516587, compound

HRID 1971807Notes

Reaction equation

HRID 1971807 reaction equation
[CH:1]1([CH2:4][N:5]([CH:29]2[CH2:34][CH2:33][CH2:32][O:31][CH2:30]2)[C:6]2[C:7]([O:27][CH3:28])=[N:8][N:9]3[C:13]([C:14]4[C:19]([O:20][CH3:21])=[CH:18][C:17]([CH2:22][O:23][CH3:24])=[CH:16][C:15]=4[O:25][CH3:26])=[CH:12][S:11][C:10]=23)[CH2:3][CH2:2]1.[P:35](=[O:39])([OH:38])([OH:37])[OH:36]>C(OCC)(=O)C>[P:35]([OH:39])([OH:38])([OH:37])=[O:36].[CH:1]1([CH2:4][N:5]([CH:29]2[CH2:34][CH2:33][CH2:32][O:31][CH2:30]2)[C:6]2[C:7]([O:27][CH3:28])=[N:8][N:9]3[C:13]([C:14]4[C:15]([O:25][CH3:26])=[CH:16][C:17]([CH2:22][O:23][CH3:24])=[CH:18][C:19]=4[O:20][CH3:21])=[CH:12][S:11][C:10]=23)[CH2:2][CH2:3]1

Participants

4

Reactant 2

HCID 1004Phosphoric AcidHCID 44478462HCID 44478462, compound

Product 1

HCID 68516587HCID 68516587, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a mixture of N-(cyclopropylmethyl)-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]-6-methoxy-N-(tetrahydro-2H-pyran-3-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine (30.0 mg) and ethyl acetate (0.6 mL) was added phosphoric acid (14.6M, 4.00 μL). The mixture was stirred at room temperature for 5 minutes and the solvent was removed by blowing nitrogen stream and dried to obtain the title compound (35.8 mg).

Workup

  1. customthe solvent was removed
  2. customdried

Sources & evidence

ORD record
ord-1a1ce97654c749379630d372f8cc8af2
Source dataset
uspto-grants-2013_04
Patent number
US08431603B2

Reaction notes

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