Methanesulfonic Acid → HCID 86635069, compound

HRID 1971809Notes

Reaction equation

HRID 1971809 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][O:9][CH3:10])[CH:5]=[C:4]([O:11][CH3:12])[C:3]=1[C:13]1[N:14]2[N:20]=[C:19]([O:21][CH3:22])[C:18]([N:23]([CH2:30][CH2:31][CH3:32])[CH:24]3[CH2:29][CH2:28][O:27][CH2:26][CH2:25]3)=[C:15]2[S:16][CH:17]=1.[CH3:33][S:34]([OH:37])(=[O:36])=[O:35]>C(OCC)(=O)C>[CH3:33][S:34]([OH:37])(=[O:36])=[O:35].[Cl:1][C:2]1[CH:7]=[C:6]([CH2:8][O:9][CH3:10])[CH:5]=[C:4]([O:11][CH3:12])[C:3]=1[C:13]1[N:14]2[N:20]=[C:19]([O:21][CH3:22])[C:18]([N:23]([CH2:30][CH2:31][CH3:32])[CH:24]3[CH2:25][CH2:26][O:27][CH2:28][CH2:29]3)=[C:15]2[S:16][CH:17]=1

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 44478733HCID 44478733, compound

Product 1

HCID 86635069HCID 86635069, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a mixture of 3-[2-chloro-6-methoxy-4-(methoxymethyl)phenyl]-6-methoxy-N-propyl-N-(tetrahydro-2H-pyran-4-yl)pyrazolo[5,1-b][1,3]thiazole-7-amine (10.7 mg) and ethyl acetate (0.5 mL) was added methanesulfonic acid (1.45 μL). The mixture was stirred at room temperature for 1 hour and the solvent was removed by blowing nitrogen stream and dried to obtain the title compound (12.8 mg).

Workup

  1. customthe solvent was removed
  2. customdried

Sources & evidence

ORD record
ord-1524ef4c7cb34eb58b6e191e66a7d679
Source dataset
uspto-grants-2013_04
Patent number
US08431603B2

Reaction notes

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