Acetic Acid → HCID 66922520, compound

HRID 1971851Notes

Reaction equation

HRID 1971851 reaction equation
[CH2:1]([O:8][C:9]1[C:14](=[O:15])[N:13]2[CH:16]=[CH:17][N:18]([CH2:19][C:20]([N:22]3[CH2:27][CH:26]([CH3:28])[O:25][CH:24]([CH3:29])[CH2:23]3)=[O:21])[C:12]2=[N:11][C:10]=1[C:30]1[S:31][C:32]([CH2:35][C:36]2[CH:41]=[CH:40][C:39]([F:42])=[CH:38][C:37]=2[S:43][CH3:44])=[CH:33][N:34]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.OO.CC(O)=[O:49]>O>[CH2:1]([O:8][C:9]1[C:14](=[O:15])[N:13]2[CH:16]=[CH:17][N:18]([CH2:19][C:20]([N:22]3[CH2:27][CH:26]([CH3:28])[O:25][CH:24]([CH3:29])[CH2:23]3)=[O:21])[C:12]2=[N:11][C:10]=1[C:30]1[S:31][C:32]([CH2:35][C:36]2[CH:41]=[CH:40][C:39]([F:42])=[CH:38][C:37]=2[S:43]([CH3:44])=[O:49])=[CH:33][N:34]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 784Hydrogen PeroxideHCID 66922532HCID 66922532, compound

Product 1

HCID 66922520HCID 66922520, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The mixture of the product of example 168 (160 mg, 0.25 mmol), H2O2 (30%, 1 ml) and HOAc (5 ml) was stirred at room temperature for 3 h. H2O (6 ml) was added and then extracted with ethyl acetate. The organic layer was washed with H2O, dried and concentrated. The residue was purified by column chromatography (ethyl acetate) to give the titled compound (170 mg, 100% yield)

Workup

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with H2O
  3. customdried
  4. concentrationconcentrated
  5. customThe residue was purified by column chromatography (ethyl acetate)

Sources & evidence

ORD record
ord-d781f21120dc44f5838fb7eb213ff680
Source dataset
uspto-grants-2013_04
Patent number
US08431581B2

Reaction notes

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