Methyl Benzoate → HCID 53410154, compound

HRID 1972114Notes

Reaction equation

HRID 1972114 reaction equation
[C:1]([O:9][CH3:10])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:11]1[CH2:16][CH2:15][CH:14](CO)[CH2:13][CH2:12]1>C1(C)C=CC=CC=1>[C:1]([O:9][CH2:10][CH:14]1[CH2:15][CH2:16][NH:11][CH2:12][CH2:13]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 7150Methyl BenzoateHCID 4207714-Piperidinemethanol

Product 1

HCID 53410154HCID 53410154, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In an argon atmosphere, a mixture of methyl benzoate (1.0 mmol), piperidin-4-ylmethanol (1.2 mmol), Zn4(OCOCF2)6O (1.25 mol % in terms of mole number) and toluene (1.7 ml) was heated to reflux for 18 hours, and as a result, piperidin-4-ylmethyl benzoate was obtained at a yield of 88%. The yield of N-benzoylpiperidin-4-ylmethyl benzoate was 12%.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 18 hours

Sources & evidence

ORD record
ord-d0abb7771cbe4cd48dc6c2b6612f19c2
Source dataset
uspto-grants-2013_04
Patent number
US08431709B2

Reaction notes

Loading…