Methyl Benzoate → HCID 178511723, compound

HRID 1972115Notes

Reaction equation

HRID 1972115 reaction equation
[C:1]([O:9][CH3:10])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:11][C@H:12]1[CH2:17][CH2:16][C@H](O)[CH2:14][CH2:13]1>C1(C)C=CC=CC=1>[C:1]([O:9][C@H:10]1[CH2:16][CH2:17][C@H:12]([NH2:11])[CH2:13][CH2:14]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 7150Methyl BenzoateHCID 178511715HCID 178511715, compound

Product 1

HCID 178511723HCID 178511723, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

In an argon atmosphere, a mixture of methyl benzoate (1.0 mmol), trans-4-aminocyclohexan-1-ol (1.2 mmol), Zn4(OCOCF3)6O (1.25 mol % in terms of mole number) and toluene (1.7 ml) was heated to reflux for 24 hours, and as a result, trans-4-aminocyclohexyl benzoate was obtained at a yield of 99%.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 24 hours

Sources & evidence

ORD record
ord-b54c1234758b4a1d8ea4036e90674af3
Source dataset
uspto-grants-2013_04
Patent number
US08431709B2

Reaction notes

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