Potassium Carbonate → HCID 86640987, compound

HRID 1972171Notes

Reaction equation

HRID 1972171 reaction equation
C([NH:9][C:10]([NH:12][C:13]1[CH:18]=[C:17]([O:19][C:20]2[C:21]([CH3:26])=[N:22][CH:23]=[CH:24][CH:25]=2)[C:16]([Br:27])=[CH:15][N:14]=1)=[S:11])(=O)C1C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+]>C(O)C>[Br:27][C:16]1[C:17]([O:19][C:20]2[C:21]([CH3:26])=[N:22][CH:23]=[CH:24][CH:25]=2)=[CH:18][C:13]([NH:12][C:10]([NH2:9])=[S:11])=[N:14][CH:15]=1

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 86640986HCID 86640986, compound

Product 1

HCID 86640987HCID 86640987, compoundYield 74%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
40 °C

Procedure

1-Benzoyl-3-(5-bromo-4-(2-methylpyridin-3-yloxy)pyridin-2-yl)thiourea (2.8 g, 6.3 mmol) and potassium carbonate (0.57 mL, 9.5 mmol) were diluted in ethanol (50 mL). The reaction was stirred at 40° C. for 5 hours, then concentrated and purified using silica gel column chromatography (eluting with ethyl acetate) to give the title compound (1.58 g, 74% yield) as light yellow solid.

Workup

  1. concentrationconcentrated
  2. custompurified
  3. washsilica gel column chromatography (eluting with ethyl acetate)

Sources & evidence

ORD record
ord-6e113340037442cbae08c5387908b36e
Source dataset
uspto-grants-2013_04
Patent number
US08431713B2

Reaction notes

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