HCID 86645369, compound → HCID 68701248, compound

HRID 1972219Notes

Reaction equation

HRID 1972219 reaction equation
[Cl:1][C:2]1[CH:42]=[CH:41][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([N:13]3[CH:17]([C:18]4[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[CH:19]=4)[CH2:16][N:15]([CH2:28][C:29]([NH:31][CH2:32][C:33]([O:35]C(C)(C)C)=[O:34])=[O:30])[C:14]3=[O:40])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1>C(Cl)Cl.C(O)(C(F)(F)F)=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][C:7]2[CH:8]=[CH:9][C:10]([N:13]3[CH:17]([C:18]4[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:27])([F:25])[F:26])[CH:19]=4)[CH2:16][N:15]([CH2:28][C:29]([NH:31][CH2:32][C:33]([OH:35])=[O:34])=[O:30])[C:14]3=[O:40])=[CH:11][CH:12]=2)=[CH:41][CH:42]=1

Participants

4

Reactant 1

HCID 86645369HCID 86645369, compound

Product 1

HCID 68701248HCID 68701248, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

tert-Butyl 2-(2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)-imidazolidin-1-yl)acetamido)acetate (20.0 mg, 0.0332 mmol) is dissolved in a mixture solvent of DCM (0.4 mL) and TFA (0.4 mL). The reaction mixture is stirred at room temperature for 3 h before removal of the solvent. The residue is purified by reparative LC/MS to provide the title compound; HPLC-MS calculated for C26H21ClF3N3O5 (M+H+) 548.1, found 548.1.

Workup

  1. customThe residue is purified by reparative LC/MS

Sources & evidence

ORD record
ord-6b5084f44b084365aae099a9aa4adb03
Source dataset
uspto-grants-2013_04
Patent number
US08431607B2

Reaction notes

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