HCID 68741356, compound → HCID 59485688, compound

HRID 1972227Notes

Reaction equation

HRID 1972227 reaction equation
[Cl:1][C:2]1[CH:45]=[CH:44][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([N:13]3[CH:17]([C:18]4[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:27])([F:26])[F:25])[CH:19]=4)[CH2:16][N:15]([CH2:28][CH2:29][N:30]4[CH2:35][CH2:34][N:33](C(OC(C)(C)C)=O)[CH2:32][CH2:31]4)[C:14]3=[O:43])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1>C(Cl)Cl.C(O)(C(F)(F)F)=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:6][C:7]2[CH:8]=[CH:9][C:10]([N:13]3[CH:17]([C:18]4[CH:23]=[CH:22][CH:21]=[C:20]([C:24]([F:27])([F:25])[F:26])[CH:19]=4)[CH2:16][N:15]([CH2:28][CH2:29][N:30]4[CH2:31][CH2:32][NH:33][CH2:34][CH2:35]4)[C:14]3=[O:43])=[CH:11][CH:12]=2)=[CH:44][CH:45]=1

Participants

4

Reactant 1

HCID 68741356HCID 68741356, compound

Product 1

HCID 59485688HCID 59485688, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 6422Trifluoroacetic acidSolvent

Procedure

tert-butyl 4-(2-(3-(4-(4-chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)imidazo-lidin-1-yl)ethyl)piperazine-1-carboxylate (15 mg, 0.023 mmol) is dissolved in a mixture solvent of DCM (0.2 mL) and TFA (0.2 mL). The reaction mixture is stirred at room temperature for 15 min before removal of the solvent. The residue is purified by reparative LC/MS to provide the title compound; HPLC-MS calculated for C28H28ClF3N4O2 (M+H+) 545.2, found 545.2.

Workup

  1. customThe residue is purified by reparative LC/MS

Sources & evidence

ORD record
ord-a7cdfaad53644994a3bcf57ab985841e
Source dataset
uspto-grants-2013_04
Patent number
US08431607B2

Reaction notes

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