反应详情

温度

80 °C

2-(3-(4-(4-Chlorophenoxy)phenyl)-2-oxo-4-(3-(trifluoromethyl)phenyl)-imidazolidin-1-yl)ethyl methanesulfonate (85.0 mg, 0.153 mmol) is dissolved in a mixture solvent of iPrOH (0.5 mL) and concentrated ammonia aqueous solution (0.5 mL). The reaction mixture is heated at 80° C. for 2 h, cooled down to room temperature, taken in H2O (10 mL), and extracted with EtOAc (3×5 mL). The combined organic layer is dried over MgSO4 and evaporated in vacuo to provide the crude title compound (69.7 mg, 96% yield) as a colorless oil-like product; HPLC-MS calculated for C24H21ClF3N3O2 (M+H+) 476.1, found 476.1.

1. temperaturecooled down to room temperature
2. extractionextracted with EtOAc (3×5 mL)
3. dry with materialThe combined organic layer is dried over MgSO4
4. customevaporated in vacuo