反应详情

温度

100 °C

A 100 ml, round-bottomed flask was charged with 3-(tetrahydro-2H-pyran-4-ylmethyl)-1-(2-thiophenylsulfonyl)piperazine hydrochloride (0.250 g, 0.681 mmol), 2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol (0.330 g, 1.02 mmol, Bioorg. Med. Chem. Lett. 2002, 12, 3009), sodium tert-butoxide (0.196 g, 2.04 mmol) and 10 mL of toluene. To this was added dicyclohexyl(2′,6′-diisopropoxybiphenyl-2-yl)phosphine (RuPhos) (0.032 g, 0.068 mmol, Strem Chemical Inc, Newburyport, Mass.), tris(dibenzylideneacetone)dipalladium (0) (0.031 g, 0.034 mmol, Strem Chemical Inc, Newburyport, Mass.). The mixture was heated at 100° C. for 12 h and then diluted with water (10 mL) and extracted with EtOAc (2×20 mL). The combined organic extracts were dried (MgSO4), concentrated, and purified by reverse-phase preparative HPLC (Phenomenex Gemini C18 column (150×30 mm, 10 μm), eluting with a 0.1% TFA in CH3CN/H2O (10% to 90% over 25 min)) to afford 1,1,1,3,3,3-hexafluoro-2-(4-(2-(tetrahydro-2H-pyran-4-ylmethyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol (0.008 g) as a mixture of two enantiomers.

1. extractionextracted with EtOAc (2×20 mL)
2. dry with materialThe combined organic extracts were dried (MgSO4)
3. concentrationconcentrated
4. custompurified by reverse-phase preparative HPLC (Phenomenex Gemini C18 column (150×30 mm, 10 μm)
5. washeluting with a 0.1% TFA in CH3CN/H2O (10% to 90% over 25 min))