Ammonium Hydroxide → HCID 66582681, compound

HRID 1972527Notes

Reaction equation

HRID 1972527 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[CH:12]=[CH:13][C:14](Cl)=[N:15][CH:16]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH4+:18].[OH-]>CCO>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[CH:12]=[CH:13][C:14]([NH2:18])=[N:15][CH:16]=2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14923Ammonium HydroxideHCID 86670384HCID 86670384, compound

Product 1

HCID 66582681HCID 66582681, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
120 °C

Procedure

5-((4-Bromophenyl)sulfonyl)-2-chloropyridine (98 mg, 0.29 mmol), concentrated NH4OH (3 mL), and EtOH (3 mL) were added to a high-pressure reaction vessel. The vessel was sealed and heated at 120° C. for 18 h. After cooling to room temperature, the solvent was partially removed under vacuum. The white precipitate obtained was filtered, washed with ether, and dried under vacuum to provide 5-((4-bromophenyl)sulfonyl)-2-pyridinamine (75 mg) as a white solid.

Workup

  1. customThe vessel was sealed
  2. temperatureAfter cooling to room temperature
  3. customthe solvent was partially removed under vacuum
  4. customThe white precipitate obtained
  5. filtrationwas filtered
  6. washwashed with ether
  7. customdried under vacuum

Sources & evidence

ORD record
ord-cf86ba39260444d4b8d421b70340d877
Source dataset
uspto-grants-2013_04
Patent number
US08431563B2

Reaction notes

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