Trifluoroacetic acid → Ethyl glycyl-3-methoxyphenylalaninate trifluoroacetate

HRID 1972547Notes

Reaction equation

HRID 1972547 reaction equation
C(OC([NH:8][CH2:9][C:10]([NH:12][C@H:13]([C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([O:21][CH3:22])[CH:16]=1)=[O:11])=O)(C)(C)C.[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31]>ClCCl>[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31].[NH2:8][CH2:9][C:10]([NH:12][C@H:13]([C:23]([O:25][CH2:26][CH3:27])=[O:24])[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([O:21][CH3:22])[CH:16]=1)=[O:11]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66582631ethyl N-(tert-butoxycarbonyl)glycyl-3-methoxyphenylalaninate

Product 1

HCID 66582605Ethyl glycyl-3-methoxyphenylalaninate trifluoroacetate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a 100-mL round-bottomed flask was added ethyl N-(tert-butoxycarbonyl)glycyl-3-methoxyphenylalaninate (812 mg, 2.13 mmol) and trifluoroacetic acid (5 mL, 67.3 mmol) in dichloromethane (5 mL). The reaction mixture was stirred at room temperature for 30 min. The solvent was removed in vacuo to give crude ethyl glycyl-3-methoxyphenylalaninate trifluoroacetate as a viscous oil which was used without purification.

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-492672fb3ae446358284d553cc99c487
Source dataset
uspto-grants-2013_04
Patent number
US08431563B2

Reaction notes

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