Hydrochloric Acid → N-(1-methylethyl)-N-((2R)-2-piperazinylmethyl)methanesulfonamide dihydrochloride
Reaction equation
[CH3:1][CH:2]([N:4]([CH2:9][C@H:10]1[CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12][N:11]1C(OC(C)(C)C)=O)[S:5]([CH3:8])(=[O:7])=[O:6])[CH3:3].[ClH:30]>CCOC(C)=O>[ClH:30].[ClH:30].[CH3:3][CH:2]([N:4]([CH2:9][C@H:10]1[CH2:15][NH:14][CH2:13][CH2:12][NH:11]1)[S:5]([CH3:8])(=[O:6])=[O:7])[CH3:1]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 70 °C
Procedure
A 150-mL round-bottomed flask was charged with di-tert-butyl (2R)-2-(((1-methylethyl)(methylsulfonyl)amino)methyl)-1,4-piperazinedicarboxylate (0.617 g, 1.42 mmol), HCl (4.0 M in 1,4-dioxane, 2.80 mL, 11.2 mmol) and EtOAc (20 mL). The mixture was heated at 70° C. for 18 h. The reaction mixture was allowed to cool to room temperature and the resulting white solid was collected by filtration. The solid was washed with EtOAc and to obtain N-(1-methylethyl)-N-((2R)-2-piperazinylmethyl)methanesulfonamide dihydrochloride (0.421 g) as a white solid.
Workup
- temperatureto cool to room temperature
- filtrationthe resulting white solid was collected by filtration
- washThe solid was washed with EtOAc
Sources & evidence
- ORD record
- ord-3ea682e7cf0f4ba68cc234b8441049a9
- Source dataset
- uspto-grants-2013_04
- Patent number
- US08431563B2
Reaction notes
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