Hydrochloric Acid → Ethyl 3-(2-methoxy-3-pyridinyl)alaninate

HRID 1972653Notes

Reaction equation

C1(C(C2C=CC=CC=2)=[N:8][C@H:9]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH2:10][C:11]2[C:12]([O:17][CH3:18])=[N:13][CH:14]=[CH:15][CH:16]=2)C=CC=CC=1.Cl>O1CCCC1>[CH3:18][O:17][C:12]1[C:11]([CH2:10][C@@H:9]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[NH2:8])=[CH:16][CH:15]=[CH:14][N:13]=1

Participants

Conditions

Temperature: 0 °C

Procedure

To a 100-mL round-bottomed flask was added ethyl N-(diphenylmethylidene)-3-(2-methoxy-3-pyridinyl)alaninate (1.52 g, 3.91 mmol) and 5N hydrochloric acid (1.72 mL, 8.61 mmol) in tetrahydrofuran (20 mL). The reaction mixture was stirred at 0° C. for 1 h. The solvent was removed in vacuo to give crude ethyl 3-(2-methoxy-3-pyridinyl)alaninate as a white tar, which was used without purification.

Workup

customThe solvent was removed in vacuo

Sources & evidence

ORD record: ord-8cd13aafa5754b1dad31a775093aa669
Source dataset: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08431563B2

Reaction notes

Loading…