Hydrochloric Acid → HCID 66582562, compound

HRID 1972660Notes

Reaction equation

HRID 1972660 reaction equation
C1(C(C2C=CC=CC=2)=[N:8][C@H:9]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[N:12]=2)C=CC=CC=1.Cl>C1COCC1>[CH3:18][O:17][C:13]1[N:12]=[C:11]([CH2:10][C@@H:9]([C:19]([O:21][CH2:22][CH3:23])=[O:20])[NH2:8])[CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86670428ethyl N-(diphenylmethylidene)-3-(6-methoxy-2-pyridinyl)alaninate

Product 1

HCID 66582562HCID 66582562, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a 100-mL round-bottomed flask was added ethyl N-(diphenylmethylidene)-3-(6-methoxy-2-pyridinyl)alaninate (1.81 g, 4.66 mmol) and 5N hydrochloric acid (1.86 mL, 9.32 mmol), and THF (20 mL). The reaction mixture was stirred at room temperature for 30 min. The solvent was removed in vacuo to give crude ethyl 3-(6-methoxy-2-pyridinyl)alaninate as a light-yellow tar, which was used without purification.

Workup

  1. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-91200790e8c147e983b4ec1e0be78d1a
Source dataset
uspto-grants-2013_04
Patent number
US08431563B2

Reaction notes

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