Hydrochloric Acid → HCID 69327017, compound

HRID 1972740Notes

Reaction equation

HRID 1972740 reaction equation
[NH2:1][C:2]1[C:7]2=[C:8]([C:25]3[CH:26]=[CH:27][C:28]4[C:32]([CH:33]=3)=[N:31][N:30]([CH2:34][C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[CH:29]=4)[CH:9]=[C:10]([CH:11]3[CH2:17][CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]3)[N:6]2[N:5]=[CH:4][N:3]=1.[ClH:41]>CO.O1CCOCC1>[ClH:41].[NH:14]1[CH2:15][CH2:16][CH2:17][CH:11]([C:10]2[N:6]3[C:7]([C:2]([NH2:1])=[N:3][CH:4]=[N:5]3)=[C:8]([C:25]3[CH:26]=[CH:27][C:28]4[C:32]([CH:33]=3)=[N:31][N:30]([CH2:34][C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[CH:29]=4)[CH:9]=2)[CH2:12][CH2:13]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58529848HCID 58529848, compound

Product 1

HCID 69327017HCID 69327017, compoundYield 100%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl 4-[4-amino-5-(2-benzyl-2H-indazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]azepane-1-carboxylate in MeOH (10 mL) was added 4M HCl in dioxane (5 mL). The mixture was stirred at rt for 5 h. The mixture was concentrated to dryness to afford 924 mg (100%) of the desired product, which contained trace impurities. LC-MS [M+H]+=438.28, RT=2.10 min.

Workup

  1. concentrationThe mixture was concentrated to dryness

Sources & evidence

ORD record
ord-f911fccbd9d440e7be62609cf15768d9
Source dataset
uspto-grants-2013_04
Patent number
US08431695B2

Reaction notes

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