Hydrochloric Acid → HCID 69302734, compound

HRID 1972742Notes

Reaction equation

HRID 1972742 reaction equation
[NH2:1][C:2]1[C:7]2=[C:8]([C:29]3[CH:30]=[CH:31][C:32]4[C:36]([CH:37]=3)=[N:35][N:34]([CH2:38][C:39]3[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=3)[CH:33]=4)[CH:9]=[C:10]([C:11]3[N:12]=[C:13]([CH:16]4[CH2:21][CH2:20][N:19](C(OC(C)(C)C)=O)[CH2:18][CH2:17]4)[S:14][CH:15]=3)[N:6]2[N:5]=[CH:4][N:3]=1.[ClH:45]>CO.O1CCOCC1>[ClH:45].[CH2:38]([N:34]1[CH:33]=[C:32]2[C:36]([CH:37]=[C:29]([C:8]3[CH:9]=[C:10]([C:11]4[N:12]=[C:13]([CH:16]5[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]5)[S:14][CH:15]=4)[N:6]4[C:7]=3[C:2]([NH2:1])=[N:3][CH:4]=[N:5]4)[CH:30]=[CH:31]2)=[N:35]1)[C:39]1[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 58529406HCID 58529406, compound

Product 1

HCID 69302734HCID 69302734, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 312751,4-DioxaneSolvent

Procedure

To a solution of tert-butyl 4-{4-[4-amino-5-(2-benzyl-2H-indazol-6-yl)pyrrolo[2,1-f][1,2,4]triazin-7-yl]-1,3-thiazol-2-yl}piperidine-1-carboxylate (586 mg, 0.97 mmol) in MeOH (4 mL) was added 4M HCl in dioxane (2 mL). The mixture was stirred at rt for 16 h. The mixture was concentrated to afford 577 mg (100%) of, the desired product, which was used without further characterization.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-691aa289a73f4c87aa8f12af838799e7
Source dataset
uspto-grants-2013_04
Patent number
US08431695B2

Reaction notes

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